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1) Product Images from "Recent Development and Applications of Polydopamine in Tissue Repair and Regeneration Biomaterials"
Article Title: Recent Development and Applications of Polydopamine in Tissue Repair and Regeneration Biomaterials
Journal: International Journal of Nanomedicine
doi: 10.2147/IJN.S437854
Figure Legend Snippet: Selected and Representative PDA Related Materials in Tissue Repair and Regeneration
Techniques Used: Adhesive, Modification, Construct
Figure Legend Snippet: ( A ) Schematic illustration of the usage and probable working principle of cross-linker adhesion system. The tissue adhesive properties of PDA NPs exhibit a correlation between higher adhesive strength and smaller particle size (* p <0.05). Reproduced with the permission from Pandey N, Soto-Garcia L, Yaman S, et al. Polydopamine nanoparticles and hyaluronic acid hydrogels for mussel-inspired tissue adhesive nanocomposites. Biomater Adv . 2022;134:112,589. Copyright © 2022, with permission from Elsevier. ( B and C ) Porous carboxymethyl chitin microspheres with PDA (CMCHm-PDA) have better hemostatic performance (clotting time and blood loss) than a wide use commercial hemostatic agents Yunnan Baiyao ® (* p <0.05). Adapted from Carbohydrate Polymers , Volume 270, Leng F, Chen F, Jiang X. Modified porous carboxymethyl chitin microspheres by an organic solvent-free process for rapid hemostasis. Pages 118348. Copyright © 2021, with permission from Elsevier.
Techniques Used: Adhesive, Coagulation, Modification, Solvent
Figure Legend Snippet: ( A ) PDA/heparin nanoparticles were prepared to improve the encapsulation efficiency and control BMP-2 release behavior. Reproduced from Wu Y, Li X, Sun Y, et al. Multiscale design of stiffening and ROS scavenging hydrogels for the augmentation of mandibular bone regeneration. Bioact Mater . 2023;20:111–125. Copyright © 2022 KeAi, open access. ( B ) Fabrication of bone morphogenetic protein-2 (BMP2)-functionalized 3D-printed P34HB scaffold via polydopamine surface modification. ( C ) The amount of attached BMP2 was observed to increase with the increasing initial concentration of BMP-2. ( D ) Percentage of released BMP2 from BMP2-functionalized 3D-printed P34HB scaffolds during 30 days incubation in PBS buffer. ( B – D ) Used with permission of Royal Society of Chemistry, from Zhang X, Li J, Chen J, et al. Enhanced bone regeneration via PHA scaffolds coated with polydopamine-captured BMP2. J Mater Chem B . 022;10(32):6214–6227. ; permission conveyed through Copyright Clearance Center, Inc. ( E ) Schematic illustration showing the PDA coating of porous microspheres and the subsequent exosome adsorption via bioinspired dopamine chemistry. Gao YK, Yuan ZY, Yuan XJ, et al. Bioinspired porous microspheres for sustained hypoxic exosomes release and vascularized bone regeneration. Bioact Mater . 2022;14:377–388. doi:10.1016/j.bioactmat.2022.01.041. Copyright © 2022 KeAi, open access.
Techniques Used: Encapsulation, Control, Modification, Concentration Assay, Incubation, Adsorption
Figure Legend Snippet: ( A ) Schematic illustration of in vivo RA therapy effect of dimethylamino group (3- dimethylamino- 1- propylamine (M) or 3, 3- iminobis (N, N- dimethylaminopropyl) ( B )) modified polydopamine (DPs). The DPs were intra articular (IA) injected into the knee joint of CIA rat and strongly bound with cfDNA to lower the expression of inflammatory factors: MMP-13, TNF-α, IL-6 and IL-1β for RA therapy. Reproduced from Chen Y, Wang Y, Jiang X, et al. Dimethylamino group modified polydopamine nanoparticles with positive charges to scavenge cell-free DNA for rheumatoid arthritis therapy. Bioact Mater . 2022;18:409–420. Copyright © 2022 KeAi, open access. ( B ) Schematic illustration of PDA@MF NPs treatment for ROS-related kidney diseases. ( C ) Bio-distribution of PDA NPs and PDA@MF NPs was examined via in vivo imaging instruments. ( D ) H&E analysis of kidneys in different groups. Adapted from Zheng B, Deng G, Zheng J, et al. Self-polymerized polydopamine-based nanoparticles for acute kidney injury treatment through inhibiting oxidative damages and inflammatory. Int J Biochem Cell Biol . 2022;143:106141. Copyright © 2022, with permission from Elsevier.
Techniques Used: In Vivo, Modification, Injection, Expressing, In Vivo Imaging